Platinum Diagnostics LLC

Platinum Diagnostics utilizes the Taqman PGx Express panel from ThermoFisher via a buccal swab

Testing is performed on a ThermoFisher QuantStudio 7Flex 

                          Drug                                                                      Gene(s)

Codeine, Tramadol, Hydrocodone, Oxycodone                            CYP2D6

Fentanyl, Buprenorphine, Oxycodone                                          CYP3A4, CYP3A5

Methadone                                                                                    CYP2B6

Alfentanil, Sufentanil, Hydromorphone, Morphine, Fentanyl         OPRM1

NSAIDs

Ibuprofen, Piroxicam, Lornoxicam, Meloxicam,                              CYP2C9

Flurbiprofen, Celecoxib, Diclofenac                                                CYP2C9

• https://cpicpgx.org/genes-drugs
• https://www.fda.gov/drugs/science-and-research-drugs/table-pharmacogenomic-biomarkers-drug-labeling

CYP2D6: This enzyme is responsible for metabolizing drugs like oxycodone and codeine. A CYP2D6 mutation can inhibit your ability to metabolize these medications, leading to inadequate pain relief. Conversely, if you metabolize them too rapidly, you may feel increased sedation and be more susceptible to addiction.

CYP3A4: This enzyme regulates opioids such as fentanyl and methadone. Metabolizing them poorly puts you at greater risk for negative side effects, such as elevated blood levels and blood toxicity.

CYP2C9: Although it plays a role in metabolizing some strong drugs, CYP2C9 is primarily responsible for metabolizing aspirin and NSAIDs (such as diclofenac). A gene mutation can cause an adverse reaction to these drugs, such as renal and gastrointestinal problems.